ocd ir initial: 50 mg PO at bedtime
ocd ir titration: Increase by 50 mg increments at intervals of at least 4 days as tolerated; divide total daily doses >100 mg/day into 2 doses
ocd ir typical: 100-300 mg/day (split if >100 mg/day)
ocd ir max: 300 mg/day (some experts may use up to 450 mg/day in select patients when well-tolerated but ineffective)
ocd er initial: 100 mg PO at bedtime
ocd er titration: Increase by 50 mg increments at intervals of at least 1 week as tolerated
ocd er typical: 100-300 mg once daily
ocd er max: 300 mg/day (some experts may use up to 450 mg/day in select patients when well-tolerated but ineffective)
gad initial: 50 mg PO once daily
gad titration: Increase in 25-50 mg increments based on response and tolerability at intervals of at least 3 days up to 100 mg/day; after 4-6 weeks may continue increasing by 50 mg every 1-2 weeks; divide doses >100 mg/day into 2 doses
gad max: 300 mg/day
panic initial: 25-50 mg PO once daily
panic titration: Increase gradually based on response and tolerability; some experts hold the lower end of the range for ~4 weeks before pushing higher; divide doses >100 mg/day into 2 doses
panic typical: 100-200 mg/day
panic max: 300 mg/day
ptsd initial: 25 mg PO twice daily OR 50 mg PO once daily
ptsd titration: Increase by 25-50 mg weekly based on response and tolerability; target 100-300 mg/day in 2 divided doses
ptsd max: 300 mg/day
social anxiety ir initial: 50 mg PO once daily
social anxiety ir titration: After 4-6 weeks at 50 mg/day, may increase by 50 mg at intervals of at least 1 week; divide doses >100 mg/day into 2 doses
social anxiety ir typical: 100-300 mg/day
social anxiety ir max: 300 mg/day
social anxiety er initial: 100 mg PO at bedtime
social anxiety er titration: After 4-6 weeks at 100 mg/day, may increase by 50 mg at intervals of at least 1 week
social anxiety er typical: 100-300 mg once daily
social anxiety er max: 300 mg/day
mdd initial: 50 mg PO once daily
mdd titration: Increase based on response and tolerability to 100-200 mg/day; divide doses >100 mg/day into 2 doses
mdd typical: 100-200 mg/day
mdd max: 300 mg/day (studied)
bdd initial: 50 mg PO once daily
bdd titration: Increase by 50 mg every 2-3 weeks based on response and tolerability; usual target 300 mg/day by weeks 6-10 (divide if >100 mg/day)
bdd typical: 300 mg/day
bdd max: 300 mg/day (some patients may require up to 450 mg/day if tolerated; adequate trial often 12-16 weeks with time at 300 mg/day if needed)
bulimia initial: 50 mg PO once daily
bulimia titration: Increase based on response and tolerability up to 300 mg/day; divide doses >100 mg/day into 2 doses
bulimia max: 300 mg/day
binge eating initial: 50 mg PO once daily
binge eating titration: Increase based on response and tolerability up to 300 mg/day; divide doses >100 mg/day into 2 doses (some trials used 3 divided doses at 300 mg/day)
binge eating max: 300 mg/day
expert low start option: Some experts start 25 mg PO daily and titrate slowly in ≤25 mg increments for anxiety-sensitive patients (activation, insomnia, nausea, dizziness, headache).